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Original article

Changes in the Incidence of Gestational Trophoblastic Disease - 2000-2010 - Our Experience

By
Biljana Lazović ,
Biljana Lazović
Vera Milenković
Vera Milenković

Abstract

Gestational trophoblastic disease (GTD) is a group of rare tumors that involve abnormal growth of cells inside a woman's uterus. The aim of the paper was to report the incidence of GTD in the University Hospital Center during a ten-year period. The retrospective analysis involved all medical records of women who were treated for GTD in our clinic. Histopathologic report of abortion specimen with gestational trophoblastic disease was registered and we calculated the incidence of births, abortions and total pregnancies.  There were 104 patients who were treated in our clinic. The overall incidence of GTD was 1,26 per 1000 deliveries. According to our experience, a lower socio economic status may be a risk factor for GTD, apart from younger age, at least one delivery and more abortions in anamnesis.

References

1.
RETIRED: Gestational Trophoblastic Disease. Journal of Obstetrics and Gynaecology Canada. 2002;24(5):434–9.
2.
Szulman AE, Surti U. The syndromes of hydatidiform mole. American Journal of Obstetrics and Gynecology. 1978;131(6):665–71.
3.
Escobar PF, Lurain JR, Singh DK, Bozorgi K, Fishman DA. Treatment of high-risk gestational trophoblastic neoplasia with etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine chemotherapy☆. Gynecologic Oncology. 2003;91(3):552–7.

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