The degree of patient cooperation plays a key role in the success of antihypertensive drug therapy. Non-adherence is the major health and economic problem in the treatment of arterial hypertension (HTA). The aim of the study was to evaluate the degree of adherence in hypertensive patients and to study risk factors affecting adherence and the effects of non-adherence on blood pressure (BP). We performed a cross-sectional study, which involved 170 outpatients with HTA, treated in primary healthcare. Patients were divided into two groups, depending on the degree of adherence, measured using a validated survey form. Statistical analysis was performed using the Pearson's Chi-square and t-test. Good adherence was observed in 126 (74.12%) outpatients. Elderly patients with longer duration of HTA and larger number of drugs in the therapy showed a lower degree of adherence, with more side-effects (p < 0.01). Patients younger than 65 years were found to be more likely to adhere to their medication regimen, compared to elderly patients (χ2 = 21.3; p < 0.01; OR = 6.0 95%, CI 2.76-13.04). Uncontrolled BP occurred in the significantly higher percentage in non-adherent patients (59.1%) compared to the adherent group (21.4%) (χ2 = 19.84; p < 0.01; OR = 5.30 95%, CI 2.39-11.85). The most common reason for poor adherence was non-compliance with dosage regimen (27.27%). The medication adherence rate was found to be low among elderly patients. A poor adherence was found to negatively affect BP control. Determining the factors for non-adherence and developing multidisciplinary intervention programs to address the identified factors are necessary to improve adherence to medication and BP control.
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
11
Eric K. P. Lee, Paul Poon, Benjamin H. K. Yip, Yacong Bo, Meng‐Ting Zhu, Chun‐Pong Yu, Alfonse C. H. Ngai, Martin C. S. Wong, Samuel Y. S. Wong
(2022)
Global Burden, Regional Differences, Trends, and Health Consequences of Medication Nonadherence for Hypertension During 2010 to 2020: A Meta‐Analysis Involving 27 Million Patients
Journal of the American Heart Association, 11(17)
10.1161/JAHA.122.026582
Ying Lau, Tha Pyai Htun, Kin Sun Chan, Piyanee Klainin-Yobas
(2017)
Multidimensional factors affecting medication adherence among community-dwelling older adults: a structural-equation-modeling approach
Journal of Public Health, 25(1)
10.1007/s10389-016-0764-1
Lipi Dhar, Jaya Dantas, Mohammed Ali
(2017)
A Systematic Review of Factors Influencing Medication Adherence to Hypertension Treatment in Developing Countries
Open Journal of Epidemiology, 07(03)
10.4236/ojepi.2017.73018
Ching Siang Tan, Mohamed Azmi Ahmad Hassali, Chin Fen Neoh, Long Chiau Ming
(2020)
Beliefs about medicine and medication adherence among hypertensive patients in the community setting
Drugs & Therapy Perspectives, 36(8)
10.1007/s40267-020-00744-8
Zahra Ahmadifajr, Saeid Foroghi, Tahere Toulabi, Mahamad Almasian
(2023)
Evaluation of the Effect of Group Hope Therapy on Reducing Anxiety and Adherence to Treatment in Hemodialysis Patients
Journal of Health Reports and Technology, 9(4)
10.5812/jhrt-140314
Stanislav Gregor
(2017)
Combination therapy for hypertension in the year 2017 - the basic knowledge for pharmacists
Praktické lékárenství, 13(1)
10.36290/lek.2017.001
Amandeep Kaur, Preeti S. Dhoat, Navdeep Kaur, Soumya S. Sahoo
(2024)
Knowledge, Awareness, and Determinants of Medication Adherence in Hypertensive Patients: A Hospital-Based Cross-sectional Study in North India
Journal of Pharmacy and Bioallied Sciences, 16(Suppl 1)
10.4103/jpbs.jpbs_406_23
Sheng-Qian Yew, Kit-Aun Tan, Ahmad Iqmer Nashriq Mohd Nazan, Rosliza Abdul Manaf
(2023)
Domains of Adherence and Non-Adherence to Anti-Hypertensive Medications in Hypertensive Patients from Kuala Lumpur: A Qualitative Study
Malaysian Journal of Medicine and Health Sciences, 19(5)
10.47836/mjmhs.19.5.11
Tenaw Baye, Fentaw Girmaw, Getachew Ashagrie, Abebe Tarekegn Kassaw
(2023)
Drug Therapy Problems and Associated Factors Among Hypertensive Patients in North Wollo Public Hospitals, Northeast Ethiopia: Institutional-Based Cross-Sectional Study
Integrated Blood Pressure Control, Volume 16()
10.2147/IBPC.S416585
Mehdi Jafari Oori, Farahnaz Mohammadi, Kian Norouzi, Masoud Fallahi-Khoshknab, Abbas Ebadi
(2019)
Conceptual Model of Medication Adherence in Older Adults with High Blood Pressure-An Integrative Review of the Literature
Current Hypertension Reviews, 15(2)
10.2174/1573402114666181022152313
Dawit Yimenu, Hui Wen Quek, Paris Rafeld, Amina Hareem, Eyob Alemayehu Gebreyohannes, Kate Wang, Liza Seubert, Kenneth Lee, Amy Theresa Page
(2025)
Understanding the language of medicines use in older adults: a systematic review of definitions and measures
International Journal of Pharmacy Practice, 33(6)
10.1093/ijpp/riaf060The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.